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ORIGINAL ARTICLE
Year : 2019  |  Volume : 62  |  Issue : 5  |  Page : 226-230

Lifetime overproduction of circulating angiotensin-(1-7) in rats attenuates the increase in skeletal muscle damage biomarkers after exhaustive exercise


1 Department of Physical Education, Federal University of Ouro Preto, Ouro Preto, MG, Brazil
2 Department of Physiology and Pharmacology, Federal University of Minas Gerais, Belo Horizonte, Brazil
3 Department of Physical Education, Federal University of Minas Gerais, Belo Horizonte, Brazil

Correspondence Address:
Dr. Emerson Cruz de Oliveira
School of Physical Education of Federal University of Ouro Preto, Ouro Preto, Minas Gerais, CEP: 35.400-000
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/CJP.CJP_57_19

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Angiotensin-(1-7) (Ang-[1-7]) can modulate glucose metabolism and protect against muscular damage. The aim of this study was to investigate the influence of lifetime increase of circulating levels of Ang-(1-7) at exhaustive swimming exercise (ESE). Sprague-Dawley (SD) and transgenic rats TGR(A1-7)3292 (TR) which overproduce Ang-(1-7) (2.5-fold increase) were submitted to ESE. The data showed no differences in time to exhaustion (SD: 4.90 ± 1.37 h vs. TR: 5.15 ± 1.15 h), creatine kinase, and transforming growth factor beta (TGF-β). Lactate dehydrogenase (SD: 219.9 ± 12.04 U/L vs. TR: 143.9 ± 35.21 U/L) and α-actinin (SD: 336.7 ± 104.5 U/L vs. TR: 224.6 ± 82.45 U/L) values were significantly lower in TR. There was a significant decrease in the range of blood glucose levels (SD: −41.4 ± 28.32 mg/dl vs. TR: −13.08 ± 39.63 mg/dl) in SD rats. Muscle (SD: 0.06 ± 0.02 mg/g vs. TR: 0.13 ± 0.01 mg/g) and hepatic glycogen (SD: 0.66 ± 0.36 mg/g vs. TG: 2.24 ± 1.85 mg/g) in TR were higher. The TR presented attenuation of the increase in skeletal muscle damage biomarkers and of the changes in glucose metabolism after ESE.


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