Chinese Journal of Physiology

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 63  |  Issue : 2  |  Page : 77--84

Ipomoea aquatica extract reduces hepatotoxicity by antioxidative properties following dichlorvos administration in rats


Mohammad Reza Salahshoor1, Amir Abdolmaleki1, Ahmad Shabanizadeh2, Amir Jalali3, Shiva Roshankhah1 
1 Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Anatomical Sciences, Immunology of Infectious Diseases Research Center, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
3 Department of Nursing, Kermanshah University of Medical Sciences, Kermanshah, Iran

Correspondence Address:
Dr. Shiva Roshankhah
Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Daneshgah Ave., Taghbostan, Kermanshah
Iran

Ipomoea aquatica (IA) with antioxidant properties is used in therapeutic trends. An organophosphate, dichlorvos (Dich), is a common insecticide with various side effects on living tissues. This study examines the role of IA on Dich-induced hepatotoxicity in male rats. Sixty-four male rats were divided into eight groups including sham, Dich (4 mg/kg/day, intraperitoneally), IA 1, 2, and 3 (250, 500, and 1000 mg/kg/day, respectively, orally), and Dich + IA 1, 2, and 3. All treatments were applied daily for 60 days. At the end of the treatment, the animals were sacrificed. The histopathological changes, leukocyte infiltration, and apoptosis were assessed by light and fluorescent microscopy. The serum levels of hepatic enzymes, nitrite oxide (NO), and total antioxidant capacity (TAC) were evaluated biochemically. Dich statistically significantly increased the NO level, hepatic enzyme activity, apoptosis, leukocyte infiltration, the mean diameter of hepatocytes (DHs), and central hepatic vein diameter (CHVD) and also decreased the TAC, mean weight of liver, and the total weight of rats compared to the sham group (P < 0.01). In all IA and Dich + IA groups, a statistically significant decrease was detected in apoptosis, leukocyte infiltration, hepatic enzyme activity, NO level, mean DH, and CHVD, whereas an increase in TAC level, mean liver weight, and total weight was detected compared to the Dich group (P < 0.01). IA, due to the antioxidant property, recovers the Dich-related catastrophic changes in liver.


How to cite this article:
Salahshoor MR, Abdolmaleki A, Shabanizadeh A, Jalali A, Roshankhah S. Ipomoea aquatica extract reduces hepatotoxicity by antioxidative properties following dichlorvos administration in rats.Chin J Physiol 2020;63:77-84


How to cite this URL:
Salahshoor MR, Abdolmaleki A, Shabanizadeh A, Jalali A, Roshankhah S. Ipomoea aquatica extract reduces hepatotoxicity by antioxidative properties following dichlorvos administration in rats. Chin J Physiol [serial online] 2020 [cited 2020 Jun 1 ];63:77-84
Available from: http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2020;volume=63;issue=2;spage=77;epage=84;aulast=Salahshoor;type=0