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  Indian J Med Microbiol
 

Figure 4: PI3 kinase signaling and interleukin-18 receptor upregulation. (a and b) Pre-treated with LY294002 (LY) significantly attenuated interleukin-18-induced H9c2 cell size increase. (c) Interleukin-18 significantly increases interleukin-18 receptor protein expression which was blunted by LY. (d) Adenine (Ade) and gold nanoparticles (Au) treatments significantly augment PI3 kinase inhibition by LY pretreatment. (n = 6) ##P < 0.01, compared with control #P < 0.01, compared with interleukin-18 **P < 0.05, compared with control

Figure 4: PI3 kinase signaling and interleukin-18 receptor upregulation. (a and b) Pre-treated with LY294002 (LY) significantly attenuated interleukin-18-induced H9c2 cell size increase. (c) Interleukin-18 significantly increases interleukin-18 receptor protein expression which was blunted by LY. (d) Adenine (Ade) and gold nanoparticles (Au) treatments significantly augment PI3 kinase inhibition by LY pretreatment. (<i>n</i> = 6) <sup>##</sup><i>P</i> < 0.01, compared with control <sup>#</sup><i>P</i> < 0.01, compared with interleukin-18 **<i>P</i> < 0.05, compared with control