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  Indian J Med Microbiol
 

Figure 1: Effects of Aloperine on PDGF-BB induced HPASMCs proliferation and DNA synthesis. HPASMCs were pre-cultured in serum free medium for 24 h, cells were treated with different concentrations of Aloperine (0.125–1 mM) for 24 h after the stimulation with PDGF-BB (20 ng/ml). Cell proliferation was examined using (a) the Cell Counting kit 8 test, and (b) bromodeoxyuridine incorporation was determined using an enzyme linked immunosorbent based assay. Data are expressed as the mean OD ± standard deviation. ##P < 0.01 versus the control group; *P < 0.05, **P < 0.01 versus cells exposed to PDGF-BB alone; n = 6. PDGF: Platelet-derived growth factor, HPASMCs: Human pulmonary artery smooth muscle cells, OD: Optical density

Figure 1: Effects of Aloperine on PDGF-BB induced HPASMCs proliferation and DNA synthesis. HPASMCs were pre-cultured in serum free medium for 24 h, cells were treated with different concentrations of Aloperine (0.125–1 mM) for 24 h after the stimulation with PDGF-BB (20 ng/ml). Cell proliferation was examined using (a) the Cell Counting kit 8 test, and (b) bromodeoxyuridine incorporation was determined using an enzyme linked immunosorbent based assay. Data are expressed as the mean OD ± standard deviation. <sup>##</sup><i>P</i> < 0.01 versus the control group; *<i>P</i> < 0.05, **<i>P</i> < 0.01 versus cells exposed to PDGF-BB alone; <i>n</i> = 6. PDGF: Platelet-derived growth factor, HPASMCs: Human pulmonary artery smooth muscle cells, OD: Optical density