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  Indian J Med Microbiol
 

Figure 4: Effects of Aloperine on the inactivation of signaling pathways in PDGF-BB stimulated HPASMCs. HPASMCs were treated with Aloperine (0.5 mM) for 24 h after treatment with 20 ng/ml PDGF-BB. The protein expression levels of (a) IKKα, (b) p-IKKα, (c) IκBα, (d) p-IκBα, (e) NF-κB p65, (f) TNF-α, (g) Cyclin E1 and (h) p27kip1 were determined by Western blot analysis. One representative image out of three independently performed experiments is shown. Values are expressed as the mean ± standard deviation. ##P < 0.01, #P < 0.05 versus the control group; **P < 0.01, *P < 0.05 versus the PDGF-BB treated cells. Vehicle; the PGDF-BB group: Platelet-derived growth factor-BB; HPASMCs: Human pulmonary artery smooth muscle cells

Figure 4: Effects of Aloperine on the inactivation of signaling pathways in PDGF-BB stimulated HPASMCs. HPASMCs were treated with Aloperine (0.5 mM) for 24 h after treatment with 20 ng/ml PDGF-BB. The protein expression levels of (a) IKKα, (b) p-IKKα, (c) IκBα, (d) p-IκBα, (e) NF-κB p65, (f) TNF-α, (g) Cyclin E1 and (h) p27<sup>kip1</sup> were determined by Western blot analysis. One representative image out of three independently performed experiments is shown. Values are expressed as the mean ± standard deviation. <sup>##</sup><i>P</i> < 0.01, <sup>#</sup><i>P</i> < 0.05 versus the control group; **<i>P</i> < 0.01, *<i>P</i> < 0.05 versus the PDGF-BB treated cells. Vehicle; the PGDF-BB group: Platelet-derived growth factor-BB; HPASMCs: Human pulmonary artery smooth muscle cells