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  Indian J Med Microbiol
 

Figure 5: Effects of resveratrol, exercise, and their combination on expressions of PI3K, Akt, IL-6, and STAT3 in skeletal muscles of obesity-induced sarcopenia mice and age-related sarcopenia senescence-accelerated mouse prone 8 (SAMP8) mice. (a and b) Western blotting for IL-6, STAT3, PI3K, and Akt protein levels in HFD-induced obesity mice. α-tubulin was used as a loading control. Quantitative analysis of PI3K, Akt, IL-6, and STAT3 levels was shown. All data are expressed mean ± standard error of the mean (SEM). *P < 0.05, compared with control.#P < 0.05, compared with HFD mice without treatment. (c and d) Western blotting of PI3K, Akt, IL-6, and STAT3 protein levels in sarcopenia SAMP8 mice. α-tubulin was used as a loading control. Quantitative analysis of PI3K, Akt, IL-6, and STAT3 levels was shown. Data were expressed as mean ± SEM. *P < 0.05, **P < 0.01, compared with SAMP8 control group. HFD: High-fat diet, LR: Low-dose resveratrol, MR: Middle-dose resveratrol, HR: High-dose resveratrol, PI3K: Phosphatidylinositol 3 kinase, IL-6: Interleukin-6, NS: No significant difference, SAMP8+Ex: Exercise training SAMP8 groups, SAMP8+Re: Resveratrol SAMP8 groups, SAMP8+Ex+Re: Combination of exercise training and resveratrol SAMP8 groups

Figure 5: Effects of resveratrol, exercise, and their combination on expressions of PI3K, Akt, IL-6, and STAT3 in skeletal muscles of obesity-induced sarcopenia mice and age-related sarcopenia senescence-accelerated mouse prone 8 (SAMP8) mice. (a and b) Western blotting for IL-6, STAT3, PI3K, and Akt protein levels in HFD-induced obesity mice. α-tubulin was used as a loading control. Quantitative analysis of PI3K, Akt, IL-6, and STAT3 levels was shown. All data are expressed mean ± standard error of the mean (SEM). *<i>P</i> < 0.05, compared with control.<sup>#</sup>P < 0.05, compared with HFD mice without treatment. (c and d) Western blotting of PI3K, Akt, IL-6, and STAT3 protein levels in sarcopenia SAMP8 mice. α-tubulin was used as a loading control. Quantitative analysis of PI3K, Akt, IL-6, and STAT3 levels was shown. Data were expressed as mean ± SEM. *<i>P</i> < 0.05, **<i>P</i> < 0.01, compared with SAMP8 control group. HFD: High-fat diet, LR: Low-dose resveratrol, MR: Middle-dose resveratrol, HR: High-dose resveratrol, PI3K: Phosphatidylinositol 3 kinase, IL-6: Interleukin-6, NS: No significant difference, SAMP8+Ex: Exercise training SAMP8 groups, SAMP8+Re: Resveratrol SAMP8 groups, SAMP8+Ex+Re: Combination of exercise training and resveratrol SAMP8 groups