Figure 6: Resveratrol induces skeletal muscle p38 MAPK and JNK activities in the skeletal muscles of obesity-induced sarcopenia mice and reduced JNK in aging-related sarcopenia senescence-accelerated mouse prone 8 (SAMP8) mice. (a) Western blotting analysis of skeletal muscle pro-inflammation showed increased levels of p-JNK and p-38 in HFD-induced obesity. α-tubulin was used as a loading control. All data are expressed mean ± standard error of the mean (SEM). *P < 0.05, compared with control. (b) Representative Western blotting analysis of p-JNK and p-P38 proteins in skeletal muscle of SAMP8 mice after exercise training, resveratrol intake or their combination was shown. α-tubulin was used as a loading control. Data are expressed as mean ± SEM. *P < 0.05, compared with SAMP8 control group. HFD: High-fat diet, LR: Low-dose resveratrol, MR: Middle-dose resveratrol, HR: High-dose resveratrol, MAPK: Mitogen-activated protein kinase, JNK: c-Jun N-terminal kinase, NS: No significant difference, SAMP8+Ex: Exercise training SAMP8 groups, SAMP8+Re: Resveratrol SAMP8 groups, SAMP8+Ex+Re: Combination of exercise training and resveratrol SAMP8 groups.