Figure 7: Resveratrol causes skeletal muscle hypertrophy in obesity-induced sarcopenia mice and age-related sarcopenia senescence-accelerated mouse prone 8 (SAMP8) mice. (a and b) Western blotting of NFATc3 and ERK1/2 protein levels in HFD-induced obesity mice groups. All data were expressed as mean ± standard error of the mean (SEM). *P < 0.05, **P < 0.01, compared with control. α-tubulin was used as a loading control. (c and d) Protein levels of NFATc3 and ERK1 by Western blotting in SAMP8 mice groups. α-tubulin was used as a loading control. Data are expressed as mean ± SEM. *P < 0.05, compared with SAMP8 control group. HFD: High-fat diet, LR: Low-dose resveratrol, MR: Middle-dose resveratrol, HR: High-dose resveratrol, NS: No significant difference, SAMP8+Ex: Exercise training SAMP8 groups, SAMP8+Re: Resveratrol SAMP8 groups, SAMP8+Ex+Re: Combination of exercise training and resveratrol SAMP8 groups.