Figure 1: Both denervation and disuse models exhibited marked atrophy with functional impairment. The sciatic nerve of the Rt. lower limb was severed in rats in the denervation group (n = 6), and rats in the disuse group (n = 6) were covered with restriction suits at their Rt. lower limbs (a). Muscular atrophy was identified from the 1st week (b). The circumference of the Rt. tibialis anterior and soleus muscles in both groups decreased considerably in the 1st week (c). Functional impairment was also confirmed in both models (d). *P < 0.05.