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ORIGINAL ARTICLE
Year : 2020  |  Volume : 63  |  Issue : 4  |  Page : 149-155

Administration of low-dose resveratrol attenuated hepatic inflammation and lipid accumulation in high cholesterol-fructose diet-induced rat model of nonalcoholic fatty liver disease


1 Department of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei; Department of Nursing, Cardinal Tien Junior College of Healthcare and Management, Yilan, Taiwan
2 Department of Internal Medicine, Division of Cardiology, Chang Gung Memorial Hospital, Taoyuan City, Taiwan
3 Department and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan City, Taiwan
4 Department and Graduate Institute of Biomedical Sciences, College of Medicine; Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan
5 Healthy Aging Research Center, Chang Gung University; Kidney Research Center, Chang Gung Memorial Hospital, Taoyuan City, Taiwan
6 Kidney Research Center; Department of Nephrology, Clinical Poison Center, Chang Gung Memorial Hospital; College of Medicine, Chang Gung University, Taoyuan City, Taiwan
7 Department and Graduate Institute of Biomedical Sciences, College of Medicine; Healthy Aging Research Center, Chang Gung University; Kidney Research Center, Chang Gung Memorial Hospital, Taoyuan City, Taiwan

Correspondence Address:
Prof. Li-Man Hung
Department of Biomedical Sciences, College of Medicine, Chang Gung University, No. 259, Wenhua 1st Road, Guishan District, Taoyuan City 33302
Taiwan
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Source of Support: This study was supported by a research grants from Chang Gung Memorial Hospital (CMRPD1K0161), CGU (EMRPD1K0381), and the Ministry of Science and Technology (MOST 105-2320-B-182-039-MY3) of Taiwan to Dr. Li-Man Hung., Conflict of Interest: None


DOI: 10.4103/CJP.CJP_43_20

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Resveratrol (RSV) has been demonstrated to ameliorate nonalcoholic fatty liver disease (NAFLD) in animal studies. However, RSV was given with the dosage that ranged from 7 to 300 mg/kg body weight (BW). Hence, the study aimed to investigate the efficacy of RSV at a lower dosage on high cholesterol-fructose diet (HCFD)-induced rat model of NAFLD. In the study, male Sprague-Dawley rats were fed with HCFD for 15 weeks. RSV was also given at a daily dose of 1 mg/kg BW for 15 days or 15 weeks by oral delivery. At sacrifice, plasma and liver specimens were acquired for detections of alanine and aspartate aminotransferases, proinflammatory cytokines, and lipid contents. Histological examinations and Western blotting analysis were performed using liver tissues. The results showed that RSV administration reduced plasma levels of aminotransferases and proinflammatory cytokines including interleukin-1 beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α) in HCFD-induced NAFLD. RSV also mitigated hepatic lipid accumulation and expression of IL-1β, IL-6, and TNF-α. Besides, phosphorylation of signal transducer and activator of transcription 3 (STAT3) was reduced with RSV supplementation in the liver of HCFD-fed rats. We concluded that low-dose RSV supplementation attenuated hepatic inflammation and lipid accumulation in HCFD-induced NAFLD. The ameliorative effect of RSV on NAFLD could be associated with downregulation of phosphorylated STAT3.


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