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REVIEW ARTICLE
Year : 2020  |  Volume : 63  |  Issue : 6  |  Page : 250-255

Long-term aerobic exercise training-induced anti-inflammatory response and mechanisms: Focusing on the toll-like receptor 4 signaling pathway


1 College of Human Development and Health, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan
2 College of Human Development and Health; Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan
3 Department of Emergency, Taipei Veterans General Hospital; Department of Emergency Medicine, School of Medicine, National Yang-Ming University, Taipei; Kinmen Hospital, Ministry of Health and Welfare, Kinmen, Taiwan
4 Department of Physiology, School of Medicine, National Yang-Ming University; Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan

Correspondence Address:
Prof. Chi-Chang Juan
Department of Physiology, School of Medicine, National Yang-Ming University, No. 155, Section 2, Li-Nong Street, Taipei 112304
Taiwan
Dr. Chorng-Kuang How
Department of Emergency, Taipei Veterans General Hospital, No. 201, Section 2, Shi-Pai Road, Taipei 112201
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/CJP.CJP_78_20

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Toll-like receptor 4 (TLR-4), which regulate inflammatory reactions, has become a popular research topic in recent years. This article reviews the latest scientific evidence on the regulation of TLR-4 by regular aerobic exercise training. The literature shows that long-term regular aerobic exercise training can effectively attenuate the expression of TLR-4 in immune cells and regulate its downstream intracellular cascade, including the p38 and PI3K/Akt signaling pathways. This further reduces cytokines secretion by inflammatory cells, which enhances immune system. We consider that the scientific evidence that long-term aerobic exercise training improves the inflammatory response provides a reasonable basis for using aerobic exercise training as a treatment for patients.


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