Chinese Journal of Physiology

REVIEW ARTICLE
Year
: 2020  |  Volume : 63  |  Issue : 6  |  Page : 250--255

Long-term aerobic exercise training-induced anti-inflammatory response and mechanisms: Focusing on the toll-like receptor 4 signaling pathway


Chien-Wei Chen1, Yu-Chi Kuo2, Chorng-Kuang How3, Chi-Chang Juan4 
1 College of Human Development and Health, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan
2 College of Human Development and Health; Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan
3 Department of Emergency, Taipei Veterans General Hospital; Department of Emergency Medicine, School of Medicine, National Yang-Ming University, Taipei; Kinmen Hospital, Ministry of Health and Welfare, Kinmen, Taiwan
4 Department of Physiology, School of Medicine, National Yang-Ming University; Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan

Correspondence Address:
Prof. Chi-Chang Juan
Department of Physiology, School of Medicine, National Yang-Ming University, No. 155, Section 2, Li-Nong Street, Taipei 112304
Taiwan
Dr. Chorng-Kuang How
Department of Emergency, Taipei Veterans General Hospital, No. 201, Section 2, Shi-Pai Road, Taipei 112201
Taiwan

Toll-like receptor 4 (TLR-4), which regulate inflammatory reactions, has become a popular research topic in recent years. This article reviews the latest scientific evidence on the regulation of TLR-4 by regular aerobic exercise training. The literature shows that long-term regular aerobic exercise training can effectively attenuate the expression of TLR-4 in immune cells and regulate its downstream intracellular cascade, including the p38 and PI3K/Akt signaling pathways. This further reduces cytokines secretion by inflammatory cells, which enhances immune system. We consider that the scientific evidence that long-term aerobic exercise training improves the inflammatory response provides a reasonable basis for using aerobic exercise training as a treatment for patients.


How to cite this article:
Chen CW, Kuo YC, How CK, Juan CC. Long-term aerobic exercise training-induced anti-inflammatory response and mechanisms: Focusing on the toll-like receptor 4 signaling pathway.Chin J Physiol 2020;63:250-255


How to cite this URL:
Chen CW, Kuo YC, How CK, Juan CC. Long-term aerobic exercise training-induced anti-inflammatory response and mechanisms: Focusing on the toll-like receptor 4 signaling pathway. Chin J Physiol [serial online] 2020 [cited 2021 Jan 27 ];63:250-255
Available from: https://www.cjphysiology.org/article.asp?issn=0304-4920;year=2020;volume=63;issue=6;spage=250;epage=255;aulast=Chen;type=0