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  Indian J Med Microbiol
 

Figure 2: Schematic representation of the cellular model for the inhibitory effect of long-term aerobic exercise training on the toll-like receptor 4 and downstream intracellular signaling pathway. Aerobic exercise training inhibited toll-like receptor 4 expression, and subsequently downregulated p38 activation or promotion phosphoinositide 3-kinase/Akt expressions, which in turn decreased nuclear factor-κB expression, leading to attenuated inflammatory cytokines secretion.

Figure 2: Schematic representation of the cellular model for the inhibitory effect of long-term aerobic exercise training on the toll-like receptor 4 and downstream intracellular signaling pathway. Aerobic exercise training inhibited toll-like receptor 4 expression, and subsequently downregulated p38 activation or promotion phosphoinositide 3-kinase/Akt expressions, which in turn decreased nuclear factor-κB expression, leading to attenuated inflammatory cytokines secretion.