Figure 6: Neuroimmune crosstalk in the spleen contributes to the programmed hypertension in HFD offspring. Time course of changes in SBP in HFD or ND offspring subjected to (a) SND or (b) treatment with nicotine infusion (1 mg/kg/day, for 7 days) at 5 weeks of age. Data are presented as mean ± SEM, n = 4–6 per group at each age. *P < 0.05 versus ND group and #P < 0.05 versus HFD group in post hoc Tukey's multiple range analysis. ND: Normal diet, SEM: Standard error of mean, HFD: High fructose diet, SBP: Systolic blood pressure, SND: Splenic nerve denervation.