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  Indian J Med Microbiol
 

Figure 3: Relationship between HSP90α expression in nipple discharge and clinicopathological parameters. (a) The expression of HSP90α showed an increasing trend from benign lesions, followed by carcinoma in situ to invasive ductal carcinoma (P < 0.0001). (b) HSP90α was positively correlated with Ki67 expression (r = 0.3639, P = 0.0480). (c) HSP90α tended to be highly expressed in patients with negative ER or PR expression (P = 0.0556 or P = 0.0584, respectively). (d-k) The expression of HSP90α in nipple discharge showed no significant correlation with grade, tumor size, LNM, HER2 expression, molecular subtype, T stage, N stage, and tumor stage. (l) In 128 patients with nipple discharge, the expression of HSP90α in nipple discharge was not significantly correlated with age and BMI. LNM: Lymph node metastasis, BMI: Body mass index, HSP90α: Heat shock proteins 90α, ER: Estrogen receptor, PR: Progesterone receptor.

Figure 3: Relationship between HSP90α expression in nipple discharge and clinicopathological parameters. (a) The expression of HSP90α showed an increasing trend from benign lesions, followed by carcinoma <i>in situ</i> to invasive ductal carcinoma (<i>P</i> < 0.0001). (b) HSP90α was positively correlated with Ki67 expression (<i>r</i> = 0.3639, <i>P</i> = 0.0480). (c) HSP90α tended to be highly expressed in patients with negative ER or PR expression (<i>P</i> = 0.0556 or <i>P</i> = 0.0584, respectively). (d-k) The expression of HSP90α in nipple discharge showed no significant correlation with grade, tumor size, LNM, HER2 expression, molecular subtype, T stage, N stage, and tumor stage. (l) In 128 patients with nipple discharge, the expression of HSP90α in nipple discharge was not significantly correlated with age and BMI. LNM: Lymph node metastasis, BMI: Body mass index, HSP90α: Heat shock proteins 90α, ER: Estrogen receptor, PR: Progesterone receptor.