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  Indian J Med Microbiol
 

Figure 3: Silence of GATA4 alleviated secretion of inflammatory factors in Aβ1–42 fibril-infused rats. (a) Injection with sh-GATA4 virus reduced TNF-α, IL-1β, and IL-6 mRNAs in hippocampus of Aβ-infused rats. (b) Injection with sh-GATA4 virus reduced TNF-α, IL-1β, and IL-6 in hippocampus of Aβ-infused rats. *** versus sham, P < 0.001. ##, ### versus Aβ + sh-NC, P < 0.01, P < 0.001. GATA4: GATA-binding protein 4, sh-GATA4: shRNA targeting GATA4, TNF-α: Tumor necrosis factor-alpha, IL: Interleukin, sh-NC: negative control.

Figure 3: Silence of GATA4 alleviated secretion of inflammatory factors in Aβ<sub>1–42</sub> fibril-infused rats. (a) Injection with sh-GATA4 virus reduced TNF-α, IL-1β, and IL-6 mRNAs in hippocampus of Aβ-infused rats. (b) Injection with sh-GATA4 virus reduced TNF-α, IL-1β, and IL-6 in hippocampus of Aβ-infused rats. *** versus sham, <i>P</i> < 0.001. <sup>##</sup>, <sup>###</sup> versus Aβ + sh-NC, <i>P</i> < 0.01, <i>P</i> < 0.001. GATA4: GATA-binding protein 4, sh-GATA4: shRNA targeting GATA4, TNF-α: Tumor necrosis factor-alpha, IL: Interleukin, sh-NC: negative control.